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  <xs:element id="ttwo_MobileMember" abstract="true" name="MobileMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_AccruedExpensesAndOtherCurrentLiabilitiesDisclosureTextBlock" abstract="false" name="AccruedExpensesAndOtherCurrentLiabilitiesDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
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  <xs:element id="ttwo_AnnualMinimumContractualObligationsLineItems" abstract="true" name="AnnualMinimumContractualObligationsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="ttwo_TermLoanMember" abstract="true" name="TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_LicensingAndMarketingMember" abstract="true" name="LicensingAndMarketingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpensesAndOtherLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpensesAndOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_AnalyticsTechnologyMember" abstract="true" name="AnalyticsTechnologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedCurrentLiabilitiesLeaseObligation" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedCurrentLiabilitiesLeaseObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_DerivativeNotionalAmountToSell" abstract="false" name="DerivativeNotionalAmountToSell" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_DebtInstrumentEventOfDefaultPercentOfPrincipalThreshold" abstract="false" name="DebtInstrumentEventOfDefaultPercentOfPrincipalThreshold" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccountsReceivableNetOfAllowances" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccountsReceivableNetOfAllowances" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionPercentageOfGrantsTiedToPerformanceMeasureAsDefinedInAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="ttwo_SoftwareDevelopmentCostsAndLicensesNoncurrent" abstract="false" name="SoftwareDevelopmentCostsAndLicensesNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_ManagementAgreement2017Member" abstract="true" name="ManagementAgreement2017Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_DepreciationAndAmortizationMember" abstract="true" name="DepreciationAndAmortizationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_RestrictedStockUnitsAndPerformanceShareUnitsMember" abstract="true" name="RestrictedStockUnitsAndPerformanceShareUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_A3550SeniorNotesDue2025Member" abstract="true" name="A3550SeniorNotesDue2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_A4000SeniorNotesDue2032Member" abstract="true" name="A4000SeniorNotesDue2032Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_SoftwareDevelopmentCostsAndLicensesDisclosureTextBlock" abstract="false" name="SoftwareDevelopmentCostsAndLicensesDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="ttwo_FullGameAndOtherMember" abstract="true" name="FullGameAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_RecurrentCustomerSpendingMember" abstract="true" name="RecurrentCustomerSpendingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_SettlementRelatedToEmployeeStockPurchasePlanShares" abstract="false" name="SettlementRelatedToEmployeeStockPurchasePlanShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ttwo_AllowanceForDoubtfulAccountsSalesReturnsAndDiscounts" abstract="false" name="AllowanceForDoubtfulAccountsSalesReturnsAndDiscounts" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_StockIssuedDuringPeriodSharesRestrictedStockAwardSettlement" abstract="false" name="StockIssuedDuringPeriodSharesRestrictedStockAwardSettlement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ttwo_SoftwareDevelopmentCostsAndLicensesDisclosureAbstract" abstract="true" name="SoftwareDevelopmentCostsAndLicensesDisclosureAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="ttwo_SoftwareInternalDevelopmentMember" abstract="true" name="SoftwareInternalDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_DerivativeNotionalAmountToBuy" abstract="false" name="DerivativeNotionalAmountToBuy" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_IPMember" abstract="true" name="IPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="ttwo_RelatedPartyTransactionAnnualManagementFee" abstract="false" name="RelatedPartyTransactionAnnualManagementFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_ZyngaIncMember" abstract="true" name="ZyngaIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_DebtInstrumentFaceAmountOfEachInstrument" abstract="false" name="DebtInstrumentFaceAmountOfEachInstrument" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_NordeusLimitedMember" abstract="true" name="NordeusLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ttwo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssets" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRightOfUseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ttwo_PCAndOtherProductsMember" abstract="true" name="PCAndOtherProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
